NCT04923737

Immunomodulatory Effects of Dexmedetomidine Infusion

Immunomodulatory Effects of Dexmedetomidine Infusion After Laparoscopic Major Abdominal Surgeries: Randomized Controlled Study

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Alexandria University · Academic / Other
• Sex: All
• Age: 25 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Anesthetic management may affect both immunostimulatory and immunosuppressive mechanisms directly by modulating immune cell function or indirectly by attenuating the stress response, Thus, the choice of anesthetic technique may affect clinical outcomes by perturbing the balance between pro- and anti-inflammatory responses,anesthetics favoring this delicate balance are thus desirable as their use may reduce postoperative complications and mortality

Conditions

• Major Abdominal Surgery

Interventions

Type	Name	Description
DRUG	Dexmedetomidine	patients will receive a loading dose of IV Dexmedetomidine1μg/kg slowly just before induction of anesthesia, then Dexmedetomidine infusion started at a rate of 0.5μg/kg/h.
DRUG	0.9% sodium chloride	patients will receive an equal volume of 0.9% sodium chloride (both the loading, and the infusion

Timeline

• Start date: 2022-01-01
• Primary completion: 2022-05-01
• Completion: 2022-05-01
• First posted: 2021-06-11
• Last updated: 2022-06-01

Locations

1 site across 1 country: Egypt