NCT04918563

Endothelium Dependent and Non-dependent Vasodilatation in Human Gingiva

Investigation of the Endothel Dependent and Independent Vasodilatation in Human Gingiva: Comparison of the Effect of NO and ACH

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Semmelweis University · Academic / Other
• Sex: All
• Age: 20 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to compare the endothelim-dependent and non-dependent vasodilatation between genders in the human gingiva.

Detailed description

Gender differences were observed in studies according to gingival microcirculation between physiological circumstances and during wound healing as well. For blood flow measurement Laser Spackle Contrast Imaging is a reliable tool. It has good reproducibility, it doesn't get in touch with the measured surface, it's easy to use and it can measure on a bigger surface in same time. Two wells were fabricated on the labial surface of the right lateral incisor (test tooth) and on the labial surface of the left central incisor (control tooth). These wells are opened towards the high-prermeability gingival sulcus, so the dropped solutions nitroglycerine vs physiological saline or nitroglycerine vs physiological saline can esasily penetrate to the gingival tissues. After applying the solutions, the blood flow was monitored fot 15 minutes.

Conditions

• Vasodilatation
• Oral Soft Tissue Conditions

Interventions

Type	Name	Description
DRUG	Nitroglycerin	Vasodilatator solution is dropped on the labial surface on the lateral incisor, so it can penetrate through the sulcus.
DRUG	Acetylcholine	Vasodilatator solution is dropped on the labial surface on the lateral incisor, so it can penetrate through the sulcus.

Timeline

• Start date: 2020-09-15
• Primary completion: 2021-04-15
• Completion: 2021-05-15
• First posted: 2021-06-09
• Last updated: 2021-06-14

Locations

1 site across 1 country: Hungary