NCT04916522

The COlchicine HypERtENsion Trial

COHERENT - The COlchicine HypERtENsion Trial

• Status: Active Not Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 150 (estimated)
• Sponsor: Herlev and Gentofte Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study to investigate the effects of colchicine on measures of vascular and cardiac function in patients with hypertension.

Detailed description

The study is an investigator-initiated, prospective, double-blind, placebo-controlled, randomized clinical trial investigating the effects of colchicine in patients with hypertension. The study population will consist of approximately 150 patients aged 18 years and above with a diagnosis of hypertension and in active treatment with at least 1 antihypertensive drug. Patients will be randomized to either low-dose colchicine treatment (0,5 mg once daily) or placebo. Treatment will continue for 6 months. Patients will be assessed by measurement of pulse wave velocity (PWV), office blood pressure, echocardiography, cardiac MRI, and blood samples at baseline and after 6 months.

Conditions

• Hypertension

Interventions

Type	Name	Description
DRUG	Colchicine	0.5 mg once daily
DRUG	Placebo	Once daily

Timeline

• Start date: 2021-08-10
• Primary completion: 2026-01-01
• Completion: 2026-01-01
• First posted: 2021-06-07
• Last updated: 2025-12-22

Locations

1 site across 1 country: Denmark