NCT04914234

Premedication With Atenolol Versus Metoprolol for Controlled Hypotensive Anesthesia During Nasal Surgeries

Premedication With Atenolol Versus Metoprolol for Controlled Hypotensive Anesthesia During Nasal Surgeries. A Randomized Clinical Trial

• Status: Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Damanhour Teaching Hospital · Other Government
• Sex: All
• Age: 21 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

Objectives: To compare the safety and efficacy of oral atenolol versus oral metoprolol as a premedication for controlled hypotensive anesthesia during nasal surgeries. Background: Mucosal bleeding is the most frequent complication with nasal surgeries, as it interferes with the optimal visualization of the intranasal anatomy, increases operation time, and consequently increases blood loss. There are several pharmacological and non-pharmacological techniques for the appropriate control of intraoperative bleeding. Patients and Methods: This was a prospective, randomized, double-blind, phase four, comparative clinical trial; carried out on 60 patients, who were candidates for nasal surgeries under general anesthesia at our hospital. Patients were randomly allocated into two equal groups; group A, received oral atenolol, and group M, received oral metoprolol.

Conditions

• Hypotension Drug-Induced

Interventions

Type	Name	Description
DRUG	Atenolol Succinate Oral Tablet	Atenolol 50 mg
DRUG	Metoprolol Succinate Oral Tablet	Metoprolol 100 mg

Timeline

• Start date: 2025-08-01
• Primary completion: 2026-01-15
• Completion: 2026-01-30
• First posted: 2021-06-04
• Last updated: 2025-08-21

Locations

1 site across 1 country: Egypt