NCT04913454

CLearing Alzheimer's Disease Molecular Pathology Without Medications

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: University Hospital, Geneva · Academic / Other
• Sex: All
• Age: 40 Years – 80 Years
• Healthy volunteers: Accepted

Summary

According to the most popular pathophysiological models of Alzheimer's disease, the amyloid hypothesis, amyloid deposition is the causative event triggering a chain of other downstream events which finally lead to Alzheimer's disease and dementia. In mouse models of Alzheimer's disease, 40 Hz multi-sensory (auditory and visual) stimulation was able to reduce the number and size of amyloid plaques throughout cortex and improve cognitive performance. The primary objective of this study is to assess whether an intervention consisting of 40 Hz multi-sensory (auditory and visual) stimulation is able to reduce the amyloid load in non-demented amyloid-positive individuals. As secondary objectives, the investigators will assess whether such intervention is able to: * improve the brain electrical activity, * improve or slow down the worsening of Alzheimer's blood-based biomarkers, * improve or slow down the worsening of cognition.

Conditions

• Alzheimer Disease
• Amyloid Plaque
• Amyloidosis

Interventions

Type	Name	Description
OTHER	40 Hz multi-sensory (auditory + visual) stimulation and cognitive training	40 Hz multi-sensory (auditory + visual) stimulation and cognitive training (1 hour/day, per 5 days/week, for a total of 8 weeks)
OTHER	Cognitive training	Cognitive training (1 hour/day, per 5 days/week, for a total of 8 weeks)

Timeline

• Start date: 2021-08-01
• Primary completion: 2022-06-30
• Completion: 2022-07-31
• First posted: 2021-06-04
• Last updated: 2021-06-04