Trials / Completed
CompletedNCT04912661
Iron and Vaccine Response
Iron and Vaccine-preventable Viral Disease - an Experimental Study
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 121 (actual)
- Sponsor
- Swiss Federal Institute of Technology · Academic / Other
- Sex
- Female
- Age
- 18 Years – 55 Years
- Healthy volunteers
- Accepted
Summary
Vaccines often underperform in Africa compared to high-income countries. Why vaccines do not work as well in Africa remains uncertain. Malnutrition likely plays a role. Our study objective is to assess whether iron deficiency anaemia in young women impairs their immune response to viral vaccines, and whether iron treatment improves their response.
Detailed description
Group 1 (immediate iron treatment) will receive iron treatment before vaccination. Women in both groups will receive two intramuscular vaccines (influenza and yellow fever). Vaccine response will be measured 28 and 56 days after vaccine administration in both groups. Group 2 (delayed iron treatment) will receive iron treatment at study end.
Conditions
- Iron Deficiency Anemia
- Vaccine Preventable Disease
- Vaccine Response Impaired
- Iron Deficiency Anemia Treatment
Interventions
| Type | Name | Description |
|---|---|---|
| DIETARY_SUPPLEMENT | Ferinject | intravenous iron carboxymaltose |
Timeline
- Start date
- 2021-05-29
- Primary completion
- 2021-09-09
- Completion
- 2021-09-09
- First posted
- 2021-06-03
- Last updated
- 2021-09-14
Locations
1 site across 1 country: Kenya
Source: ClinicalTrials.gov record NCT04912661. Inclusion in this directory is not an endorsement.