NCT04912193

Antithrombin III and Post-liver Transplantation Acute Kidney Injury

Low Preoperative Antithrombin III Level is Associated With Postoperative Acute Kidney Injury After Liver Transplantation

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 2,395 (actual)
• Sponsor: Asan Medical Center · Academic / Other
• Sex: All
• Age: 19 Years
• Healthy volunteers: —

Summary

The reno-protective effect of Antithrombin III (ATIII) has been well-studied in various animal studies; however, little is known about the effect of ATIII on kidney function in patients undergoing liver transplantation (LT). This study aimed to determine the association between preoperative ATIII level and postoperative acute kidney injury (AKI) after LT (post-LT AKI).

Conditions

• Liver Transplantation and Antithrombin

Interventions

Type	Name	Description
DRUG	Antithrombin III	In liver transplant recipients with baseline antithrombin III levels lower than 50%, exogenous Antithrombin III was administrated during the anhepatic phase of the liver transplant surgery.

Timeline

• Start date: 2010-01-04
• Primary completion: 2019-01-31
• Completion: 2019-12-31
• First posted: 2021-06-03
• Last updated: 2021-06-03

Locations

1 site across 1 country: South Korea

Regulatory

• FDA-regulated drug study