NCT04905446

Measurement of NAD+ Synthesis in Human Skeletal Muscle

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: AdventHealth Translational Research Institute · Academic / Other
• Sex: Male
• Age: 21 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The key objective of this pilot research study is to dose human volunteers with a heavy (non-radioactive) isotope derivative of nicotinamide to detect NAD synthesis in human skeletal muscle. The ultimate goal is to examine the impact of lifestyle choices, aging, nutraceuticals, and drugs on the rate of NAD synthesis in human subjects.

Conditions

• Skeletal Muscle

Interventions

Type	Name	Description
OTHER	Deuterated nicotinamide (D4-NAM) IV infusion	Nicotinamide adenine dinucleotide (NAD) is a vitally important substance that is found in all cells of the body. D4-NAM (in normal saline) will be infused via an indwelling catheter.The IV infusion will continue for 8 hrs.
PROCEDURE	Skeletal muscle biopsy	Participants will have a muscle biopsy performed on the muscle in the thigh. We will collect a small sample of blood before the biopsy. This procedure is used to sample muscle cells from the right or left leg Vastus Lateralis (thigh) muscle.
PROCEDURE	Skin tissue biopsy	This procedure is used to sample skin tissue from the upper thigh via a punch biopsy.

Timeline

• Start date: 2021-09-10
• Primary completion: 2022-06-14
• Completion: 2024-12-20
• First posted: 2021-05-27
• Last updated: 2025-03-13

Locations

1 site across 1 country: United States