Trials / Active Not Recruiting
Active Not RecruitingNCT04904692
Virological and Immunological Monitoring in Patients (suspected Of/confirmed With) COVID-19
- Status
- Active Not Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 109 (actual)
- Sponsor
- University Hospital, Ghent · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
This study is a prospective, observational multicentric study. The study population entails adult patients hospitalized with a high clinical suspicion of COVID-19 and consists of two study arms (SARS-CoV2- vs. SARS-CoV2+).This combined fundamental research project has a dual goal: on the one hand assessing immunological predisposing factors for severe infection and investigating the immunological impact of SARS-CoV2 infection, on the other hand studying viral characteristics. Furthermore, a substudy will examine the pharmacokinetics and pharmacodynamics of hydroxychloroquine in patients receiving this antiviral treatment (REVIVE susbstudy). To answer these research questions, samples will be collected from patients with a high clinical suspicion of COVID-19, hospitalized at UZ Gent and 2 participating hospitals in Ghent (AZ Maria Middelares en AZ Jan Palfijn).
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Blood draw | 8x9mL EDTA tubes. In subjects treated with hydroxychloroquine treatment an extra EDTA tube (4mL) will be collected for the REVIVE substudy. |
| PROCEDURE | Bronchoalveolar lavage | Only in case of diagnostic or therapeutic indication. |
| PROCEDURE | SARS CoV-2 swabs | Nasopharyngeal, oropharyngeal and nasal swabs |
Timeline
- Start date
- 2020-03-23
- Primary completion
- 2020-07-23
- Completion
- 2024-09-30
- First posted
- 2021-05-27
- Last updated
- 2024-09-19
Locations
3 sites across 1 country: Belgium
Source: ClinicalTrials.gov record NCT04904692. Inclusion in this directory is not an endorsement.