NCT04899778

Do Oral Contraceptives Protect Against ACL Injuries in Female Athletes

Do Oral Contraceptives Protect Against Anterior Cruciate Ligament Injuries in Female Athletes

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 73 (actual)
• Sponsor: Cedars-Sinai Medical Center · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The purpose of this research study is to examine the impact of one type of commonly used birth control pill on blood levels of relaxin and measure changes in knee movement to determine whether there are changes in joint instability (indicating the knee is less stable) that may predispose female athletes to injury. Women not on hormonal birth control will also be enrolled to analyze differences between athletes on and not on birth control and to evaluate typical relaxin levels and knee laxity when birth control pills are not used.

Conditions

• Ligament Injury

Interventions

Type	Name	Description
DRUG	Oral Contraceptive Pill, norethindrn a-e estradiol-iron	tablet

Timeline

• Start date: 2021-09-29
• Primary completion: 2023-11-20
• Completion: 2024-06-30
• First posted: 2021-05-24
• Last updated: 2025-05-01
• Results posted: 2025-05-01

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study