NCT04898023

Zinc and Green Tea Extract for Community Respiratory Viral Infections

Evaluation of Combination Zinc and Green Tea Extract Supplementation on Reduction in Symptom Duration and Severity Associated With Community Respiratory Viral Infections: a Randomized Control Trial (ZiPhenol Study)

• Status: Terminated
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 17 (actual)
• Sponsor: University of Missouri-Columbia · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Zinc and green tea supplementation have both been independently studied for supporting immune health during cold and flu-like illness in non-hospitalized patients with clinical trials demonstrating promising but inconsistent results. Combination therapy may offer an improved effect as the antioxidant compounds found in green tea have been shown to increase cellular zinc concentrations thereby inhibiting viral replication. This study seeks to evaluate the effect of combination supplementation using established doses of zinc and green tea extract on symptom duration and severity from cold and flu-like illness, including COVID-19, in adult community patients enrolled in a randomized placebo-controlled trial.

Conditions

• Respiratory Viral Infection

Interventions

Type	Name	Description
DRUG	zinc-green tea extract-ascorbic acid	Compounded capsules containing each zinc citrate, green tea extract, and ascorbic acid.
DRUG	Placebo	Compounded capsules containing microcrystalline cellulose.

Timeline

• Start date: 2022-09-21
• Primary completion: 2023-10-31
• Completion: 2023-12-20
• First posted: 2021-05-24
• Last updated: 2025-03-07
• Results posted: 2025-03-07

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study