NCT04896489

Neuroimaging Mechanisms by Which Memory and Glucocorticoids Promote Risky Drinking

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 27 (actual)
• Sponsor: Yale University · Academic / Other
• Sex: All
• Age: 21 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine whether hydrocortisone biases formation of alcohol-related memories to potentiate drinking.

Detailed description

This study aims to 1) Characterize the effect of elevated glucocorticoids during encoding on long-term memory for alcohol-related information; 2) Identify the neural mechanisms by which glucocorticoids influence encoding of alcohol-related experiences; and 3) Determine how glucocorticoid modulation of alcohol-related encoding relates to drinking after retrieving alcohol-related memories.

Conditions

• Alcohol Drinking
• Drinking Behavior
• Episodic Memory
• Long-term Memory

Interventions

Type	Name	Description
DRUG	Hydrocortisone 20 MG	Participants receive Hydrocortisone 20 MG
OTHER	Placebo	Participants receive placebo

Timeline

• Start date: 2021-05-12
• Primary completion: 2022-03-15
• Completion: 2022-03-15
• First posted: 2021-05-21
• Last updated: 2022-06-02

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study