NCT04894526

Alternating Energy Intake and Blood Fat Content After a Meal

The Effect of Alternating Energy Intake Compared to Regular Energy Intake on the Fat Content in the Blood After a Meal in Abdominally Obese Adults

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 23 (estimated)
• Sponsor: Maastricht University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

Increasing evidence suggests that meal timing affects metabolic health. For example, intermittent fasting (IF) may have positive effects on plasma glucose and lipid levels, insulin sensitivity, and blood pressure. However, IF protocols often result in significant weight loss. Therefore, it is not clear to what extent these beneficial metabolic effects are due to IF or to weight loss. Although the effect of IF independent of weight loss has been studied, daily energy intake in those studies did not differ between the days. Therefore, the investigators aim to examine the effect of alternating energy intake - i.e. standardised day-to-day fluctuations in energy intake - on metabolic health independent of weight loss.

Conditions

• Abdominal Obesity
• Postprandial Lipemia
• Lipid Metabolism
• Glucose Metabolism

Interventions

Type	Name	Description
OTHER	Alternating Energy Intake	To alternate between caloric overconsumption (130% of usual total energy needs) and caloric underconsumption (70% of usual total energy needs) on a daily basis for 6 days/week followed by one ad libitum day for 4 weeks.
OTHER	Regular Energy Intake	To consume the usual energy intake (100% of total energy needs) on a daily basis for 6 days/week, also followed by one ad libitum day for 4 weeks.

Timeline

• Start date: 2021-07-14
• Primary completion: 2022-12-01
• Completion: 2022-12-01
• First posted: 2021-05-20
• Last updated: 2022-08-26

Locations

1 site across 1 country: Netherlands