NCT04892823

Social Relationships and Accelerated Aging in Hematopoietic Cell Transplant Survivors

Accelerated Biological and Phenotypic Aging in Hematopoietic Cell Transplant Survivors: Social Support as a Protective Factor

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 110 (estimated)
• Sponsor: Medical College of Wisconsin · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This project aims to elucidate the important protective elements of social relationships and identify concrete, modifiable behavioral factors that contribute to biological and phenotypic aging in hematopoietic cell transplantation (HCT) survivors and can be used to develop biologically informed interventions to improve quality of life and prolong the healthspan of individuals with accelerated aging.

Detailed description

PRIMARY OBJECTIVES: I. Examine associations between social support, strain, and isolation and phenotypic aging over the 1-year recovery period. II. Examine associations between social support, strain, and isolation and biological aging over the 1-year recovery period. III. Test biological aging as a mediator linking social processes and phenotypic aging. EXPLORATORY OBJECTIVE: I. Test sex differences in Aims 1 and 2. OUTLINE: Adopting a prospective design, participants will complete comprehensive assessments of social processes at 100 days and 1 year after HCT that combine reports of social support, strain, and isolation with a naturalistic observation tool, the Electronically Activated Recorder (EAR), which captures ambient sound bites to assess social interactions in survivors' daily lives16. At each time point, participants will also provide reports of symptoms to characterize phenotypic aging, including cognitive, physical, and functional complaints, and blood samples to assess biological aging, including cellular senescence, DNA damage, SASP, and cellular stress using genome-wide RNA sequencing. Relevant clinical information that could influence biological aging will also be collected from patients' medical records to consider as covariates.

Conditions

• Hematopoietic and Lymphoid Cell Neoplasm

Interventions

Type	Name	Description
PROCEDURE	Biospecimen Collection	Undergo collection of blood sample
OTHER	Electronic Health Record Review	Review of medical records
OTHER	Questionnaire Administration	Complete questionnaires

Timeline

• Start date: 2021-05-18
• Primary completion: 2026-05-31
• Completion: 2026-05-31
• First posted: 2021-05-19
• Last updated: 2025-07-16

Locations

1 site across 1 country: United States