NCT04891926

Hormonal Influences on Diuresis

Influence of Hormonale Changes on Diuresis and LUTS in the Gynaecological Population

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 70 (actual)
• Sponsor: University Hospital, Ghent · Academic / Other
• Sex: Female
• Age: 40 Years
• Healthy volunteers: Accepted

Summary

The aim of this study was to observe the effect of hormonal treatment (oral or transdermal substitution therapy) on diuresis (salt and water diuresis) and lower urinary tract symptoms (LUTS) in postmenopausal women

Conditions

• Nocturia
• Menopause
• LUTS
• Diuresis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	ICIQ FLUTS Questionaires	Questionnaire observing the impact on voiding disfunctions
DIAGNOSTIC_TEST	Frequency Volume Chart	Frequency Volume Chart measures the voided volumes and fluid intake during 3 days in order to observe patients bladder capacity, total and nighttime voided volume and voiding frequency
DIAGNOSTIC_TEST	Renal Function Profile	The RFP is a 24-hour urine analysis in which urine samples are collected at fixed time points every 3 hours, starting 3 hours after the first morning void. This RFP was collected on a separated day to the FVC. Daytime samples were taken between 10:00-11:30 (U1), 13:00-15:30 (U2), 16:00-17:30 (U3), 19:00-20:30 (U4), and 22:00-23:30 (U5). The night-time samples were taken between 1:00-2:30 (U6), 4:00-5:30 (U7) and 7:00-8:30 (U8), and the volume of each interim void, was noted to calculate the 24h, daytime and night-time urine volume and diuresis rate. On each of this 8 samples, creatinine, osmolality, sodium and urea concentration were analysed. Subsequently, the renal clearance of creatinine, solutes, sodium and potassium (Usubst x Uflow / Psubst) and FWC (urine flow - solute clearance) were calculated.
DIAGNOSTIC_TEST	Blood Analysis	Blood analysis in order to observ postmenopausal state, osmolalitity and sodium.

Timeline

• Start date: 2015-05-01
• Primary completion: 2018-09-30
• Completion: 2018-09-30
• First posted: 2021-05-19
• Last updated: 2021-05-19