NCT04891627

Gingival Crevicular IL-34 and CSF-1 Levels in Patients With Periodontitis and Uncontrolled Type 2 Diabetes

Usak University Faculty of Dentistry

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 76 (actual)
• Sponsor: Uşak University · Academic / Other
• Sex: All
• Age: 20 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Type 2 diabetes mellitus is a metabolic disorder. There is a bidirectional association between periodontal disease and DM. Currently there is no data relationship between CSF-1 and IL-34, periodontal disease and diabetes.The aim of this study to investigate GCF levels of IL-34 and CSF-1 in periodontitis subjects with diabetes.

Detailed description

Periodontally healthy (H), periodontitis, and periodontitis with diabetes patients, were recruited for this study. 1. Inclusion criteria for H groups: Individuals with clinically healthy gingiva, no attachment and bone loss, and less than 10% bleeding on probing were included. 2. Inclusion criteria for periodontitis groups: Systemically healthy individuals with interdental CAL ≥ 5 mm and PPD ≥ 6 mm were included. 3. Inclusion criteria for periodontitis with diabetes groups: Type 2 diabetes patients with interdental CAL ≥ 5 mm, PPD ≥ 6 mm, and HbA1c ≥ 6.5% were included. The plaque index (PI), gingival index (GI), presence of bleeding on probing (BOP), PD, and clinical AL were used for clinical periodontal assessments. All assessments were done with a manual probe. GCF samples were obtained and analyzed using an enzyme-linked immunosorbent assay.

Conditions

• Periodontitis
• Diabetes

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Gingival crevicular fluid	GCF samples were collected in the morning hours 24-48 hours after clinical periodontal measurement.

Timeline

• Start date: 2021-01-06
• Primary completion: 2021-04-21
• Completion: 2021-05-04
• First posted: 2021-05-18
• Last updated: 2023-01-12

Locations

1 site across 1 country: Turkey (Türkiye)