NCT04891393

The Effects of Caffeine on Human Spinal Motoneurons

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Temple University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

This study evaluates the effects of orally ingested, commercially available, coffee (3 mg/kg of caffeine) on the excitability of human spinal motoneurons of the lower leg.

Detailed description

Recently, it has been shown that human spinal motoneurons do not simply act as a binary control system. Instead, they are regulated by intrinsic properties that can elicit lingering effects on the descending motoneuron. Caffeine, one of the world's most popular over-the-counter supplements, can potentially augment these characteristics of motoneurons. Using decomposition software and non-invasive, high-density surface electromyography, it is possible to extract the characteristics of these motoneurons. This project will utilize a double-blind, inactive-placebo controlled, crossover design study to examine and quantify the effects of caffeine on motoneuron excitability.

Conditions

• Healthy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Coffee	Starbucks brand "Via" instant coffee. (Caffeine Content: 3 mg / kg)
DIETARY_SUPPLEMENT	Decaffeinated coffee	Starbucks brand "Via" instant decaffeinated coffee. (Caffeine Content: 15 - 25 mg)

Timeline

• Start date: 2021-06-01
• Primary completion: 2022-03-28
• Completion: 2022-03-28
• First posted: 2021-05-18
• Last updated: 2022-04-08

Locations

1 site across 1 country: United States