Trials / Completed
CompletedNCT04889573
Immunoglobulin Gene Rearrangement and Repair in Healthy Donors
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 120 (actual)
- Sponsor
- University Hospital, Limoges · Academic / Other
- Sex
- All
- Age
- 18 Years – 70 Years
- Healthy volunteers
- Accepted
Summary
B-cells ensure humoral immune response against antigens (Ag) thanks to their receptor (BCR). V(D)J rearrangement, somatic hypermutation, immunoglobulin (Ig) class switch and locus suicide recombination are mutational/recombinational processes targeting Ig loci influencing BCR expression. Study of these events is essential for B cell function analysis. Our project will provide the normal reference values using high throughput sequencing-based protocols.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| GENETIC | Blood sample | The blood samples will be collected from healthy volunteers : 7 tubes of 7 ml with anti-coagulant Héparine Lithium and 1 tube of 7ml with anti-coagulant EDTA |
Timeline
- Start date
- 2021-07-07
- Primary completion
- 2021-10-14
- Completion
- 2021-10-14
- First posted
- 2021-05-17
- Last updated
- 2025-07-30
Locations
1 site across 1 country: France
Source: ClinicalTrials.gov record NCT04889573. Inclusion in this directory is not an endorsement.