Trials / Active Not Recruiting
Active Not RecruitingNCT04877041
Exercise and Cardiac Stunning During HD
Trial of Intradialytic Cycling as Kidney Exercise Rehabilitation for Cardiac Stunning in Hemodialysis (TICKERS-HD)
- Status
- Active Not Recruiting
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 160 (estimated)
- Sponsor
- University of Manitoba · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of this study is to determine the effect of a 12-week cycling during hemodialysis program on hemodialysis-induced myocardial stunning in adult individuals receiving hemodialysis.
Detailed description
People with kidney failure receiving chronic hemodialysis (HD) suffer from post-HD treatment fatigue, poor functional status and high rates of cardiac failure and death. Previous work has shown that these outcomes are correlated with recurrent ischemic cardiac injury (myocardial stunning) that occurs during HD treatments. Myocardial stunning, identified by regional cardiac wall motion abnormalities (RWMA), is common during HD. Intradialytic cycling (during HD) decreases HD-induced stunning, and may improve adverse outcomes associated with stunning. We will use echocardiography (echo) to understand the effects of intradialytic aerobic exercise on myocardial stunning and HD-related symptoms.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| BEHAVIORAL | Intradialytic Cycling | This intervention will consist of intradialytic cycling for 60 minutes 3 times per week for a total of 12 weeks. |
Timeline
- Start date
- 2023-03-01
- Primary completion
- 2026-01-01
- Completion
- 2026-03-01
- First posted
- 2021-05-07
- Last updated
- 2025-11-20
Locations
6 sites across 2 countries: Australia, Canada
Source: ClinicalTrials.gov record NCT04877041. Inclusion in this directory is not an endorsement.