NCT04875715

Prospective Evaluation of Topical Almond Oil vs Hydroquinone

Prospective Evaluation of Topical Almond Oil vs Hydroquinone on the Appearance of Facial Pigmentation and the Stability of the Microbiome

• Status: Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: University of California, Davis · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to analyze facial pigmentation and skin microbiome changes after topical almond oil application, compared to the use of topical hydroquinone.

Detailed description

The purpose of this experiment is to analyze facial pigmentation and skin microbiome changes after topical almond oil application, compared to the use of topical hydroquinone. There will be a total of 50 subjects: * 25 randomized to receive almond oil nightly * 25 randomized to receive 2% hydroquinone nightly Study Timelines: * The duration of an individual subject's participation will last from the day of the consent/screening (visit 1) until visit 5 where they will have images taken and measurements collected to assess skin pigment, skin hydration, sebum excretion rate. * The duration of participation is 4 months. * The estimated time for the investigators to complete primary analysis is 2 years.

Conditions

• Skin Pigmentation

Interventions

Type	Name	Description
OTHER	Almond Oil	Almond oil
DRUG	Hydroquinone Topical	Hydroquinone 2% cream

Timeline

• Start date: 2021-07-01
• Primary completion: 2026-08-01
• Completion: 2026-08-01
• First posted: 2021-05-06
• Last updated: 2025-09-12

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study