Trials / Completed
CompletedNCT04873180
Significance of Immunohistochemical Expression of Survivin in Renal Cell Carcinoma
A Retrospective Study
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 40 (actual)
- Sponsor
- Sohag University · Academic / Other
- Sex
- All
- Age
- 30 Years – 70 Years
- Healthy volunteers
- Not accepted
Summary
detection of Survivin expression in renal cell carcinoma and correlate this expression to tumor grade and stage.
Detailed description
renal cell carcinoma is the third most prevalent malignant tumor of the genitourinary system. deregulation of apoptosis is involved in carcinogenesis by abnormally prolonged cell survival, facilitating accumulations of multiple mutations and augment resistance to immune-surveillance. Survivin is a member of inhibitor of Apoptosis Protein family (IAPs). it play a role in cell cycle regulation by inhibiting apiptosis. Survivin is over-expressed in many human neoplasms.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | sectioning and staining of renal neoplasms after nephrectomy operation | nephrectomy operations will be done to patients diagnosed as having renel tumors |
Timeline
- Start date
- 2020-01-01
- Primary completion
- 2020-06-30
- Completion
- 2020-12-30
- First posted
- 2021-05-05
- Last updated
- 2021-05-07
Locations
1 site across 1 country: Egypt
Source: ClinicalTrials.gov record NCT04873180. Inclusion in this directory is not an endorsement.