NCT04872530

Bioavailability of Plant Protein Amino Acids

Bioavailability of Amino Acids and Metabolic Products Following Oral Ingestion of Plant-Based Proteins in Young, Healthy Men and Women Aged 18-35y

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: University of Limerick · Academic / Other
• Sex: Male
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

This study aims to inform of the mechanism of action of plant-based protein by measuring the bioavailability (i.e. rate of appearance and magnitude of concentration in the circulation following oral ingestion) of key amino acid and metabolic products that regulate skeletal muscle protein synthesis (MPS) in humans.

Detailed description

Plant-based proteins contain several amino acids that are essential to signal muscle growth/repair and act as a substrate during muscle protein synthesis. However, compared to animal protein or free-amino acids, the bioavailability of certain essential amino acids may be compromised. Following selective processing (e.g. removal of carbohydrate and/or other anti-nutritive factors) food grade plant-based protein concentrates possibly confer greater bioavailability and bioactivity in vivo. This project explores the bioavailability and bioactivity of selected plant-based protein concentrates following oral ingestion in young, healthy men and women.

Conditions

• Bioavailability of Amino Acids Following Oral Ingestion of Plant-Based Proteins in Young, Healthy Men

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Pea-protein concentrate	Pea-protein concentrate
DIETARY_SUPPLEMENT	Fava-bean protein concentrate	Fava-bean protein concentrate
DIETARY_SUPPLEMENT	Chickpea protein concentrate	Chickpea protein concentrate
DIETARY_SUPPLEMENT	Red lentil protein concentrate	Red lentil protein concentrate
DIETARY_SUPPLEMENT	Non-essential amino acid blend	Non-essential amino acid blend
DIETARY_SUPPLEMENT	Whey protein concentrate	Whey protein concentrate

Timeline

• Start date: 2020-01-08
• Primary completion: 2021-05-31
• Completion: 2023-09-29
• First posted: 2021-05-04
• Last updated: 2023-11-30

Locations

1 site across 1 country: Ireland