NCT04872361

Which Ventilatory Strategy is Better for Lung in Upper Abdominal Surgeries?

Ultrasonographic Assessment of Atelectasis in Major Upper Abdominal Surgeries With Different Ventilatory Strategies

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 117 (estimated)
• Sponsor: Mansoura University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Ventilated Patients especially those undergoing upper abdominal surgeries are prone to lung atelectasis. They are at risk of adverse effects secondary to inadequate lung ventilation. Applied PEEP and Recruitment maneuver are thought to enhance lung aeration under general anesthesia which could be assessed by ultrasound.

Detailed description

The aim of our study is to assess the effect of using PEEP with and without recruitment maneuver on atelectasis and lung aeration during open upper abdominal surgeries by ultrasonography. Application of PEEP improves intraoperative oxygenation and thus could minimize the incidence of postoperative atelectasis and respiratory complications during abdominal surgeries. A recent study found that PEEP and RM prevented intraoperative aeration loss, which didn't persist after extubation when comparing effects of positive end-expiratory pressure/recruitment maneuvers with zero end-expiratory pressure on atelectasis during open gynecological surgery by ultrasonography

Conditions

• Anesthesia Induced Atelectasis

Interventions

Type	Name	Description
PROCEDURE	Low PEEP	Patients will be ventilated with a PEEP of 4 cm H2O and no RMs throughout the study
PROCEDURE	High PEEP	PEEP of 10 cm H2O will be applied
PROCEDURE	High PEEP/RM	PEEP of 10 cm H2O and RM (30 cm H2O for 30 s) immediately after the second lung ultrasonographic examination and repeated every 30 minutes till emergence
DEVICE	Lung ultrasonogrphy assessment	The thorax will divided into 12 quadrants, each of them will be assigned a score of 0-3 as 0, normal lung sliding with fewer than three single B lines 1. three or more B lines 2. coalescent B lines 3. consolidated lung. The LUS (0-36) will be calculated with higher scores indicating more aeration loss

Timeline

• Start date: 2021-05-01
• Primary completion: 2022-06-01
• Completion: 2022-10-01
• First posted: 2021-05-04
• Last updated: 2021-05-04

Locations

1 site across 1 country: Egypt