NCT04871360

Effect of L-Citrulline Supplementation on NAFLD in Adolescents With Obesity

Effect of Oral L-Citrulline Supplementation on Liver Function and Non-Alcoholic Fatty Liver Disease in Adolescents With Obesity

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 42 (actual)
• Sponsor: Universidad de Guanajuato · Academic / Other
• Sex: All
• Age: 15 Years – 19 Years
• Healthy volunteers: Not accepted

Summary

One of the comorbidities of obesity is nonalcoholic fatty liver disease (NAFLD). L-citrulline is a non-protein amino acid that has shown positive effects on the degree of fat retention and metabolic profile in NAFLD. The objective is to assess the effect of oral L-citrulline supplementation on liver function and nonalcoholic fatty liver in adolescents with obesity. A clinical study will be carried out in 40 adolescents (15-19 years) with obesity, they will be divided into a control group that will receive a placebo and an experimental group that will receive 6 g of l-citrulline per day for eight weeks.

Detailed description

It is hypothesized that l-citrulline supplementation decreases liver enzymes and the degree of hepatic steatosis in adolescents with obesity. The aim of the study is to assess the effect of oral L-citrulline supplementation on liver function and nonalcoholic fatty liver in adolescents with obesity. A prospective randomized, double-blind clinical study will be carried out in 40 adolescents (15-19 years) with obesity, they will be divided into a control group that will receive a placebo (carboxymethyl cellulose) and an experimental group that will receive 6 g of pure l-citrulline per day per eight weeks. At the beginning and end of the intervention, anthropometric, biochemical and metabolic data will be evaluated, as well as tests of function and degree of hepatic steatosis.

Conditions

• Non-Alcoholic Fatty Liver Disease
• Obesity

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	L-Citrulline supplement	The intervention will consist of oral supplementation of six grams of pure l-citrulline for eight weeks.
DIETARY_SUPPLEMENT	Carboxymethyl cellulose supplement	The intervention will consist of oral carboxymethyl cellulose supplementation as a placebo.

Timeline

• Start date: 2021-05-05
• Primary completion: 2021-12-19
• Completion: 2022-01-15
• First posted: 2021-05-04
• Last updated: 2022-01-19

Locations

1 site across 1 country: Mexico