NCT04870320

Study of Attention and Memory Treatments for Cancer Survivors

A Pilot Study of A Novel Cognitive Intervention for Cancer Survivors

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 49 (actual)
• Sponsor: University of California, San Francisco · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This clinical trial investigates if certain electronic games may be effective in improving attention and memory function in cancer survivors. Cancer related cognitive impairment (CRCI) is an issue experienced by many cancer patients/survivors. CRCI includes perceived or objective problems with memory, executive function, and attention/concentration. CRCI has a negative impact on survivors' ability to work, carry out routine activities, and engage in social and family relationships. CRCI may result in significant distress and reduced quality of life. Certain electronic games may help improve attention and memory function in cancer survivors and reduce symptoms of CRCI.

Detailed description

PRIMARY OBJECTIVES: I. Determine the recruitment and retention rates for both arms of this study. II. Determine the effect size for changes in cognitive function (i.e., Test of Variables of Attention (TOVA) \[i.e. attention\], Adaptive Cognitive Evaluation (ACE) \[i.e. working memory\]) in the intervention group compared to the control group following the 4-week study. III. Evaluate adherence rates for and satisfaction with the interventions. IV. Evaluate for treatment-related adverse events (e.g., nausea, motion sickness). SECONDARY OBJECTIVE: I. To determine effect sizes for depression, fatigue, and sleep disturbance, by comparing changes in the intervention group to changes in the control group, following the 4-week study. OUTLINE: Patients are randomized to 1 of 2 arms. ARM I: Patients play Endeavor over 25 minutes daily 5 days a week for 4 weeks. ARM II: Patients play Words! over 25 minutes daily 5 days a week for 4 weeks.

Conditions

• Hematopoietic and Lymphoid Cell Neoplasm
• Malignant Solid Neoplasm

Interventions

Type	Name	Description
BEHAVIORAL	Endeavor: Computer-Based Cognitive Stimulation Intervention	Endeavor application will be utilized by participant on iPad
BEHAVIORAL	Words!: Computer-Based Cognitive Stimulation Intervention	Words! application will be utilized by participant on iPad
OTHER	Quality of Life (QOL) Questionnaires	Standardized QOL questionnaire will be administered at each study visit

Timeline

• Start date: 2021-03-01
• Primary completion: 2022-01-31
• Completion: 2022-01-31
• First posted: 2021-05-03
• Last updated: 2022-04-08

Locations

1 site across 1 country: United States