NCT04866771

Remotely Supervised tDCS for Slowing ALS Disease Progression

Remotely Supervised Transcranial Direct Current Stimulation for Slowing Disease Progression in Amyotrophic Lateral Sclerosis (ALS)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 14 (actual)
• Sponsor: University of Illinois at Chicago · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Most ALS care is centered on patient support and symptom management, making rehabilitation an integral aspect for slowing disease progression, prolonging life span, and increasing quality of life. Brain stimulation has been increasingly explored as a promising neuromodulatory tool to prime motor function in several neurological disorders. We propose a novel mechanism using remotely supervised brain stimulation to preserve motor function in individuals with ALS. This project will also aim to explore the effectiveness of brain stimulation on upper and lower motor neuron mechanisms in individuals with ALS.

Conditions

• Amyotrophic Lateral Sclerosis (ALS)

Interventions

Type	Name	Description
OTHER	Transcranial Direct Current Stimulation (tDCS)	Noninvasive brain stimulation
OTHER	Sham tDCS + anodal tDCS	Fake noninvasive brain stimulation or anodal noninvasive brain stimulation

Timeline

• Start date: 2021-08-27
• Primary completion: 2024-07-01
• Completion: 2025-01-01
• First posted: 2021-04-30
• Last updated: 2025-08-07
• Results posted: 2025-08-07

Locations

1 site across 1 country: United States