NCT04863456

Efficiency and Safety of Different Treatment Strategies in Adults With Pituitary Adenomas With Hypothalamic Involvement

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (estimated)
• Sponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Prospective and randomized evaluate efficiency and safety of different treatment strategies for hypothalamus-invading pituitary adenomas (HIPA)

Detailed description

There are various treatment strategies for hypothalamus-invading pituitary adenomas (HIPA), such as total resection (TR), subtotal resection with radiosurgery (STR+RS), etc. However,the optimal treatment of HIPA is still controversial. In this study, we want to evaluate the efficiency and safety of different treatment strategies in adults with HIPA.

Conditions

• Pituitary Adenoma

Interventions

Type	Name	Description
PROCEDURE	Total resection	Total resection of HIPA in a single surgery
PROCEDURE	Staged resection	HIPA was resected subtotally at first time, and the tumor remnant was removed at a later date
PROCEDURE	Subtotal resection followed by stereotactic radiation therapy	HIPA was resected subtotally at first time, and the tumor remnant was controled by the stereotactic radiation therapy

Timeline

• Start date: 2021-05-01
• Primary completion: 2023-12-31
• Completion: 2024-12-31
• First posted: 2021-04-28
• Last updated: 2021-04-28