NCT04863027

Use of Dual Energy Computed Tomography in Thoracic Radiotherapy Planning.

PHASE I-II Study on the Use of Dual Energy Computed Tomography for Assessment of Lung Function in Thoracic Conventional and Stereotactic Body Radiotherapy

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 60 (estimated)
• Sponsor: Centre hospitalier de l'Université de Montréal (CHUM) · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is a prospective observational study aiming: 1) To quantify lung function using perfusion dual energy computed tomography (DECT) and use this information at the time of treatment planning with preferential sparing of functional lung parenchymal 2) to validate results of lung function obtained using DECT with lung perfusion scintigraphy results, the current standard method; 4) to compare dosimetry of whole lungs vs. functional lungs in patients treated with either stereotactic body radiotherapy (SBRT) for early stage lung cancer or conventional radiotherapy for locally advanced lung cancer and 5) to evaluate lung function 6, 12 and 24 months post-radiotherapy with both perfusion DECT and pulmonary function tests and compare radiation dose-map to functional lung-map.

Conditions

• Lung Cancer
• Lung Function Decreased
• Radiation Pneumonitis

Interventions

Type	Name	Description
RADIATION	Thoracic radiotherapy	Patients will have pre-treatment and post-treatment perfusion DECT for baseline and post-treatment lung function

Timeline

• Start date: 2015-01-01
• Primary completion: 2022-11-01
• Completion: 2022-11-01
• First posted: 2021-04-28
• Last updated: 2022-11-16

Locations

1 site across 1 country: Canada