NCT04859036

The Effect of Transcatheter Ventricular Septal Defect Closure on Heart Rate Variability Parameters

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 37 (actual)
• Sponsor: Kayseri City Hospital · Other Government
• Sex: All
• Age: 56 Months – 136 Months
• Healthy volunteers: Accepted

Summary

In this study; we evaluated the heart rate variability parameters of pediatric patients whose VSDs were closed with the transcatheter method before and after, and compared with the control group.

Detailed description

Heart rate variability (HRV) is a sign of cardiac autonomic nervous system. Evaluation of HRV in pediatric ventricular septal defect (VSD) cases before and after transcatheter closure will enlighten us in terms of cardiac autonomic control. Methods: 19 VSD cases treated with transcatheter closure method and 18 healthy children were enrolled in the study. 24 hours Holter rhythm monitorization was applied to all patients before closure of VSD and to the control group. In the patient group, Holter rhythm monitorization was repeated in the third months. HRV parameters were obtained from Cardio Scan Premier 12® program. Frequency domain (Total power, VLF, LF, HF, LF/HF ratio) and time domain analysis (SDNN, SDANN, SDNNi, pNN50, rMSSD) were applied.

Conditions

• Ventricular Septal Defect
• Closure; Interventricular Septum
• Autonomic Nervous System Imbalance

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	24 hours ambulatory Holter monitoring

Timeline

• Start date: 2016-04-01
• Primary completion: 2017-04-01
• Completion: 2017-04-01
• First posted: 2021-04-26
• Last updated: 2021-04-26

Locations

1 site across 1 country: Turkey (Türkiye)