NCT04856410

Effects of Long-Duration Spaceflight on General and Spatial Cognition and Its Neural Basis

Temporal Nature of Cognitive and Visuospatial Brain Domain Changes During Long-Duration Low-Earth Orbit Missions (Spatial Cognition)

• Status: Enrolling By Invitation
• Phase: N/A
• Study type: Interventional
• Enrollment: 14 (estimated)
• Sponsor: University of Pennsylvania · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

This study investigates the effects of extended-duration spaceflight (12-month International Space Station missions) on general cognitive performance (measured with the Cognition test battery), spatial cognition, structural and functional brain changes in general, and hippocampal plasticity more specifically relative to the shorter 6-month and 2-month missions.

Detailed description

This is an international proposal consisting of two projects with synergistic aims that will be carried out in a joint effort by the National Aeronautics and Space Administration (NASA) and the German Aerospace Center (DLR) as well as the European Space Agency (ESA). The project targets NASA's particular interest in studying the 'Cognitive-perceptual-visuospatial brain domain changes due to isolation and confinement' as part of the Complement of Integrated Protocols for Human Exploration Research (CIPHER) project on the International Space Station (ISS). The collected data will demonstrate whether prolonging mission duration to one year will have detrimental effects on general cognitive performance (measured with the Cognition test battery), spatial cognition, structural and functional brain changes in general, and hippocampal plasticity more specifically relative to the shorter 6-month and 2-month ISS missions. Using state-of-the-art neuroimaging techniques, investigators will determine the biological basis for any changes in cognitive performance, with a focus on hippocampal plasticity and spatial cognition. Similar data already gathered on the ISS and in several short- and long-duration space analog environments will be used to generate a normative data base for long-duration missions. Finally, investigators will derive dose-response relationships between cognitive-visuospatial brain domain changes and mission duration that will allow predicting vulnerability to adverse cognitive or behavioral impairment and psychiatric disorders on interplanetary expeditions such as a mission to Mars. The two projects will deliver a highly unique and comprehensive set of integrated neuroimaging and neurocognitive tools for the evaluation and ultimately prevention of adverse effects on brain structure and function that lead to behavioral effects associated with exploration-type missions.

Conditions

• Brain Structure
• Cognitive Performance

Interventions

Type	Name	Description
OTHER	Spaceflight	Exposure to the spaceflight environment on the International Space Station for 2, 6, or 12 months.
OTHER	Controls	No intervention

Timeline

• Start date: 2021-08-01
• Primary completion: 2027-06-30
• Completion: 2028-06-30
• First posted: 2021-04-23
• Last updated: 2025-10-10

Locations

3 sites across 2 countries: United States, Germany