NCT04853563

Comparison of PEEP in Acute Decompensated Heart Failure

Comparison of High VErsus Low Positive End-Expiratory Pressure in Mechanically Ventilated Patients With Acute Heart Failure (HELP-AFH) : Open-label Randomized Controlled Multi-center Pilot Study

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: Asan Medical Center · Academic / Other
• Sex: All
• Age: 19 Years
• Healthy volunteers: Not accepted

Summary

Little is known about optimal level of positive end-expiratory pressure (PEEP) in patiens who recieved invasive mechanical ventilation for acute decompensated heart failure. We therefore sought to compare clinical outcome according to low versus high PEEP.

Conditions

• Heart Decompensation
• Mechanical Ventilation Pressure High

Interventions

Type	Name	Description
OTHER	PEEP	High PEEP targeted to 10 cmH2O to be maintained during the period of mechanical ventilation compared with low PEEP maintaining 3-5 cmH2O

Timeline

• Start date: 2021-04-20
• Primary completion: 2023-07-30
• Completion: 2024-04-30
• First posted: 2021-04-21
• Last updated: 2022-02-23

Locations

1 site across 1 country: South Korea