NCT04853212

The Role of Intestinal Microbiota Dysbiosis in the Development of Spondyloarthritis

The Role of Dysbiosis of Intestinal Microbiota in the Development of Spondyloarthritis

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Assistance Publique - Hôpitaux de Paris · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The primary objective of this case-control study aims to explore the role of bacterium Ruminococcus gnavus (R. gnavus) with intestinal biopsy and faecal sampling in the initiation and the development of spondyloarthritis (SPA) in comparison with health control subjets (patients without chronic disease but have indication to digestive endoscopy).

Detailed description

As secondary objectives, the study aims: * to research the abundance of bacterial strain of R. gnavus in mucosal sampling by biopsy; * to study the interaction between R. gnavus bacterium and mucus from histological sampling; * to correlate the expression of genes of intestinal mucus with the variations of identified microbiota of mucus biopsy; * to study the interaction between bacteria and intestinal epithelial cells during culture; * to demonstrate perturbations of the immune responses by dysbiosis.

Conditions

• Spondyloarthritis
• Ruminococcus Gnavus

Interventions

Type	Name	Description
PROCEDURE	Biopsy	Biopsy during recto-coloscopy

Timeline

• Start date: 2021-06-14
• Primary completion: 2026-05-01
• Completion: 2026-05-01
• First posted: 2021-04-21
• Last updated: 2025-03-19

Locations

1 site across 1 country: France