NCT04852588

Chest Lymph Node Sampling in Patients With Advanced Lung Cancer to be Treated With Curative-intent Radiation Treatment

Endoscopic Nodal Staging in Oligometastatic Non-small Cell Lung Cancer (NSCLC) Being Treated With Stereotactic Ablative Radiotherapy (ENDO-SABR)

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 29 (estimated)
• Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study will investigate the role of sampling suspicious chest lymph nodes with a procedure called endobronchial ultrasound-guided transbronchial fine needle aspiration (EBUS-TFNA) or transesophageal ultrasound-guided fine needle aspiration (EUS-FNA) in patients planned to receive radical dose radiation. This study will use Stereotactic Ablative Radiotherapy (SABR) for treatment methods. SABR is a newer radiation treatment that delivers high-dose, precise radiation to small tumors and can be delivered more accurately than with older radiation treatment methods. It is considered a standard treatment for small lung cancers, and select cancers that have spread to the brain. The purpose of this study is to compare if the lymph node sampling procedure is valuable for determining the extend of nodal disease in metastatic Non-Small Cell Lung Cancer (NSCLC) compared to imaging alone.

Conditions

• Non-Small Cell Lung Cancer

Interventions

Type	Name	Description
PROCEDURE	Endobronchial ultrasound-guided transbronchial fine needle aspiration (EBUS-TFNA)	Chest lymph node sampling procedure by EBUS
PROCEDURE	Transesophageal ultrasound-guided fine needle aspiration (EUS-FNA)	Chest lymph node sampling procedure by EUS

Timeline

• Start date: 2021-11-09
• Primary completion: 2025-05-31
• Completion: 2025-05-31
• First posted: 2021-04-21
• Last updated: 2025-03-28

Locations

2 sites across 1 country: Canada