NCT04852406

Protocol-based Management and Perioperative Outcomes in Patients With Chronic Antithrombotic Therapy

Effect of Protocol-based Management on Perioperative Outcomes in Patients With Chronic Antithrombotic Therapy: a Pragmatic Interventional Study

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 526 (estimated)
• Sponsor: Peking University First Hospital · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The purpose of this pragmatic interventional study is to evaluate whether a protocol-based management of antithrombotic drugs can reduce a composite of perioperative outcomes in patients with chronic antithrombotic therapy before surgery.

Detailed description

Aging population and chronic medical disease make the management of surgical patients more complex. About one tenth of patients scheduled for surgery are taking antithrombotic medications. Coagulation disturbance induced by these medications may increase the risk of bleeding, whereas withholding these medications may increase the risk of thrombotic events. It is a dilemma when managing these patients. The guidelines and expert consensus published by multiple disciplinary teams constitute the perioperative antithrombotic management protocols. However, the effects of perioperative antithrombotic management guided by these guidelines or expert consensus are seldom reported. The investigators hypothesize that a protocol-based perioperative antithrombotic management can benefit patients with chronic antithrombotic therapy before surgery.

Conditions

• Antithrombotic Therapy
• Perioperative Care
• Perioperative Outcomes

Interventions

Type	Name	Description
DRUG	Protocol-based management of perioperative antithrombotic therapy	Perioperative antithrombotic therapy is managed according to the latest expert consensus published in the Chinese Medical Journal, 2020.
DRUG	Routine management of perioperative antithrombotic therapy	Perioperative antithrombotic therapy is managed according to current routine practice.

Timeline

• Start date: 2021-04-21
• Primary completion: 2025-12-01
• Completion: 2026-01-01
• First posted: 2021-04-21
• Last updated: 2025-07-31

Locations

1 site across 1 country: China