NCT04847193

Hop Compounds and Immune System

Effect of Iso-alpha-Acids and Xanthohumol on Inflammatory Processes in Human

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: University of Vienna · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The aim of the present study is to determine the effect of Xanthohumol and Iso-alpha-acids from hops on the immune response of healthy participants.

Detailed description

In this placebo-controlled crossover study a study drink enriched with either a placebo, Xanthohumol, Iso-alpha Acids or a combination of latter is given to the participants. A washout phase before intervention and between each intervention is introduced. On day one of each intervention blood is drawn in fasted state from each participant. Subsequently the study drink combined with a standardized breakfast is given to the participants following a second blood drawing one hour after the consumption of the study drink. On the last day of each intervention blood is taken from study participants in the same manner as on day one. To assess the effect of Xanthohumol and Iso-alpha acids or a combination of both, clinical chemical parameters e.g. ALT, AST, γ-GT, blood lipids (triglycerides, total cholesterol, HDL, LDL), blood glucose, uric acid and CRP are determined. Furthermore, PBMC's isolated from blood samples of each time point were stimulated for either 24 or 48 h. Protein levels and mRNA expression of markers of inflammation is measured in PBMC's and supernatant of stimulated cells.

Conditions

• Inflammatory Response

Interventions

Type	Name	Description
OTHER	Dietary Intervention 1: Placebo	Participants receive a study drink supplemented with a placebo for 5 days
OTHER	Dietary Intervention 2: Xanthohumol and Iso-alpha acids	Participants receive a study drink supplemented with xanthohumol, Iso-alpha acids or a combination of both for 5 days

Timeline

• Start date: 2019-06-13
• Primary completion: 2021-01-27
• Completion: 2021-01-27
• First posted: 2021-04-19
• Last updated: 2022-03-22

Locations

1 site across 1 country: Austria