NCT04845607

Prophylactic Amiodarone for Shockable Cardiac Arrest

Prophylactic Amiodarone for Shockable Cardiac Arrest During Targeted Post Cardiac Arrest Care: Multi-center, Open Labelled Randomized Controlled Trial

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 302 (estimated)
• Sponsor: Won Young Kim · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to determine whether the prophylactic amiodarone can prevent re-arrest with ventricular shockable rhythm in patients who treated with targeted temperature management after return of spontaneous circulation from cardiac arrest which had been shockable rhythm during CPR.

Detailed description

Patients with cardiac arrest are in high risk of re-arrest during post cardiac arrest care due to vulnerable heart state electrically and hemodynamically. Especially if patients who had experienced shockable rhythms such as ventricular fibrillation or pulseless ventricular tachycardia during CPR, then they are at high risk of developing shockable re-arrest. However until now there has not been any evidence of prophylactic anti arrhythmic drug effect during post cardiac arrest care. Amiodarone is class III anti arrhythmic drug which has been used for conversion of ventricular arrhythmia during CPR. In this study we want to determine whether the prophylactic amiodarone can prevent re-arrest with ventricular shockable rhythm or not.

Conditions

• Cardiac Arrest
• Ventricular Arrythmia

Interventions

Type	Name	Description
DRUG	Amiodarone Injection	Amiodarone continuous infusion during 24 hours from return of spontaneous circulation.

Timeline

• Start date: 2021-04-01
• Primary completion: 2023-02-28
• Completion: 2023-02-28
• First posted: 2021-04-15
• Last updated: 2021-06-21

Locations

1 site across 1 country: South Korea