NCT04843137

Acute Mechanisms of Cervical Transcutaneous Electrical Stimulation of the Spinal Cord

Investigating the Acute Effects of Transcutaneous Electrical Stimulation Parameters on Neural Circuits, Motoneuron Behavior and Motor Performance in Individuals With Cervical Spinal Cord Injury

• Status: Withdrawn
• Phase: —
• Study type: Observational
• Enrollment: 0 (actual)
• Sponsor: University of Louisville · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to examine how delivery of subthreshold electrical stimulation of the spinal cord alters the excitability of neural pathways and consequently movement performance in healthy and spinal cord injured individuals. Specifically, we assess how stimulation parameters such as electrode configurations and stimulation frequency affect spinal excitability, corticospinal excitability, intracortical excitability, motor unit properties and force production. This study is not an intervention study, but a mechanistic study trying to shed light on how this novel neuromodulatory technique acutely affects the central nervous system.

Conditions

• Spinal Cord Injuries

Interventions

Type	Name	Description
DEVICE	Cervical Transcutaneous Electrical Spinal Cord Stimulation	Surface electrodes are placed over the cervical spinal cord. Constant current is delivery through these electrodes. Stimulation frequency and electrode configuration are manipulated, and outcome measures are recorded.

Timeline

• Start date: 2021-04-06
• Primary completion: 2022-02-22
• Completion: 2022-02-22
• First posted: 2021-04-13
• Last updated: 2023-10-30

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study