NCT04841772

Exploring Muscle Breakdown During Exercise Recovery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 26 (actual)
• Sponsor: University of Exeter · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

This study will allow researchers to explore how muscle responds to heavy exercise. The researchers will characterise rates of muscle protein breakdown and synthesis 24hours after heavy exercise with a post exercise protein polyphenol or placebo supplementation. This will inform strategies to help people recover from heavy exercise.

Detailed description

It is well known that resistance exercise increases rates of muscle protein synthesis and breakdown, with the rise in synthesis greater in magnitude and duration. The time course of rates of muscle protein synthesis increase dramatically 24-72h following eccentric exercise, even in a non-exercised control leg. This data is consistent with a much larger increase in muscle protein breakdown than previously thought. However, the response of muscle protein breakdown following damaging eccentric exercise, and its relationship with muscle protein synthesis, has not yet been elucidated. Moreover, it is unclear whether a protein and polyphenol nutritional intervention influence rates of muscle protein breakdown to accelerate recovery. This study will allow researchers to test the hypothesis that eccentric exercise increases rates of muscle protein breakdown independently of muscle contraction per se. If this hypothesis is supported, it will highlight that recovery strategies from muscle damage should also target supporting muscle protein breakdown.

Conditions

• Muscle Damage
• Healthy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Recover Vegan Protein Supplement	Post exercise protein supplement (26g pea protein)
DIETARY_SUPPLEMENT	Placebo	Post exercise placebo supplement (32g maltodextrin)

Timeline

• Start date: 2021-04-08
• Primary completion: 2022-12-01
• Completion: 2022-12-01
• First posted: 2021-04-12
• Last updated: 2023-03-23

Locations

1 site across 1 country: United Kingdom