NCT04841135

Blood Microbiota Signature of Alzheimer's Disease

Analysis of the Blood Signature of the Microbiota as a Diagnostic Marker of Alzheimer's Disease in the Early Stages of the Process: Pilot Study

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: University Hospital, Montpellier · Academic / Other
• Sex: All
• Age: 50 Years – 85 Years
• Healthy volunteers: Accepted

Summary

This study aims to validate a difference in blood microbial signature between Alzheimer's patients and control subjects in order to propose potential innovative strategies

Detailed description

This is a pilot study only carried out in Montpellier, aimed at comparing AD patients with control subjects, including men / women aged between 50 and 85 years. The diagnosis of AD patients is based on international criteria. Metagenomics and proteomics will be used to determine the composition of the microbiota in whole blood and stools, but also the metabolomic profile in plasma, stool and the urines.

Conditions

• Alzheimer Disease
• Elderly With Normal Cognition

Interventions

Type	Name	Description
OTHER	Multiomics quantification	One time blood, stool and urine samples will be taken.
OTHER	Polysomnography	Facultative polysomnography

Timeline

• Start date: 2021-06-03
• Primary completion: 2024-04-01
• Completion: 2026-01-01
• First posted: 2021-04-12
• Last updated: 2023-04-20

Locations

1 site across 1 country: France