NCT04840043

Osteopathic Sympathetic Harmonization and Depression

Assessment of Effectiveness of the Osteopathic Sympathetic Harmonization Applications on the Sympathetic Nervous System and the HPA Axis With Depression Diagnosed Adolescents: A Double-blind, Placebo-controlled, Randomized Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 39 (actual)
• Sponsor: Cumhuriyet University · Academic / Other
• Sex: All
• Age: 15 Years – 21 Years
• Healthy volunteers: Not accepted

Summary

Depression appears to be resistant to the available pharmacological treatments. Autonomic responses accompanied by any psychological stress are sympathetic nervous system (SNS) and neuroendocrine responses are formed by hypothalamus-pituitary-adrenal (HPA) axis. The purpose of this study is; assessment of effectiveness of osteopathic approach on sympathetic nervous system and HPA axis in adolescents with depression.

Detailed description

Depression diagnosed and volunteer to participate 39 cases who between the ages of 15-21 included. All participants were recruited and randomly assigned into two groups, the osteopathy group (OG) and the placebo group (PG). Stimulation on the sympathetic truncus and prevertebral ganglia were performed in the OG group. The stimulation of the PG group was performed with a lighter touch and a shorter duration in similar areas. Each participant was filled in the demographic data form, Beck Depression Scale and State and Trait Anxiety Inventory (STAI Form - 1 and Form - 2) before the application. Emotional state visual analog scale and STAI Form - 1 was filled and blood pressure and pulse measurement were made and saliva sample was taken before application, immediately after application and 20 minutes after application.

Conditions

• Osteopathic Manipulative Treatment

Interventions

Type	Name	Description
OTHER	Osteopathic sympathic harmonization	Treatments that harmonize at the sympathetic nerves or plexus, e.g., sympathetic trunk stimulation by means of the rib-raise technique or stimulation of the prevertebral ganglia.
OTHER	Sham intervention	Different location, size and time of the rib-raise technique or stimulation of the prevertebral ganglia.

Timeline

• Start date: 2017-10-11
• Primary completion: 2018-03-23
• Completion: 2018-06-05
• First posted: 2021-04-09
• Last updated: 2021-04-09

Locations

1 site across 1 country: Turkey (Türkiye)