NCT04839159

Study of Biological Markers in Children With Sickle Cell Disease

Prospective Clinical Study on Early Inflammatory, Cell Adhesion and Hemostatic Plasmatic Markers of Endothelial Dysfunction in Children With Sickle Cell Disease (SCD)

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 41 (estimated)
• Sponsor: Queen Fabiola Children's University Hospital · Academic / Other
• Sex: All
• Age: 6 Months
• Healthy volunteers: Not accepted

Summary

Sickle cell disease is associated with significant morbi-mortality hence the interest in an early and targeted care. At present, there is no plasmatic marker able to identify infants at higher risk of developping severe complications later in life. However, recent studies have demonstrated a correlation between certain complications of the disease and biomarkers of the endothelial dysfunction characterizing it. Investigators prospectively followed a cohort of children diagnosed with SCD through the universal neonatal screening using inflammatory and haemostatic plasmatic markers to study their annual evolution. Investigators then will evaluate potential associations between these biological markers and the occurrence of SCD related complications. A secondary objective of this study is to evaluate the repercussions of therapeutic intervention on these markers. .

Conditions

• Sickle Cell Disease

Interventions

Type	Name	Description
OTHER	Blood sampling	Blood sampling at the age of 6 and 12 months, 2-3-4 years
OTHER	Blood sampling	Blood sampling before any new sickle cell disease treatment as determined by a physician according to the standard of care to which the hospital adheres

Timeline

• Start date: 2012-05-10
• Primary completion: 2021-06-30
• Completion: 2021-06-30
• First posted: 2021-04-09
• Last updated: 2021-04-09

Locations

3 sites across 1 country: Belgium