NCT04838678

Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)

Sympathetic Neural Patterns and Transduction in Obesity-associated Hypertension

• Status: Recruiting
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: University of Texas Southwestern Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to understand how the nervous system communicates to blood vessels to increase blood pressure during stress. The study will also investigate how hypertension and obesity influence the nervous system and vascular function. The study will involve measuring sympathetic nervous system activity and blood flow during common laboratory physiological stress protocols (e.g. hypoxia, exercise), and in response to infusion of drugs that cause vasodilation or vasoconstriction.

Conditions

• Hypertension
• Obesity

Interventions

Type	Name	Description
DRUG	Neuropeptide Y	intra-arterial infusion of neuropeptide Y

Timeline

• Start date: 2021-07-18
• Primary completion: 2026-08-31
• Completion: 2026-08-31
• First posted: 2021-04-09
• Last updated: 2025-08-24

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study