NCT04829110

Alcohol Induced de Novo Lipogenesis in Women

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 27 (actual)
• Sponsor: University of Texas Southwestern Medical Center · Academic / Other
• Sex: All
• Age: 21 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The study is cross-sectional is design. In the first Aim of this study, 5 women and 5 men will be asked to consume 2g/kg of \[2H\]water (a.k.a. deuterium oxide or heavy water) which incorporates 2H tracers into newly synthesized fatty acids and triglycerides. Deuterated water is not radioactive and has a long history of application in human studies. Researchers will collect blood samples 2 hours before and 5 hours after the participants consume 20 grams of alcohol as vodka to measure alcohol induced hepatic de novo lipogenesis (DNL) in both men in women. In addition, for Aim 2 researchers will recruit an additional 10 women who will be randomized into one of two groups who will consume a beverage containing vodka and sucrose, or sucrose alone. Aim 2 will be identical to the experimental scheme in Aim 2 in order to determine if sucrose enhances the effects of vodka on hepatic DNL.

Conditions

• Liver Metabolism

Interventions

Type	Name	Description
OTHER	ETOH	Participants will consume Vodka
OTHER	Sucrose	Participants will consume sucrose in solution with water

Timeline

• Start date: 2021-11-11
• Primary completion: 2026-03-31
• Completion: 2026-03-31
• First posted: 2021-04-02
• Last updated: 2025-04-04

Locations

1 site across 1 country: United States