NCT04829071

Cognition and Motor Learning Post-stroke

Cognition as a Moderator of Motor Learning Post-stroke

• Status: Recruiting
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 65 (estimated)
• Sponsor: University of Southern California · Academic / Other
• Sex: All
• Age: 45 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

This project seeks to determine how post-stroke cognitive impairment moderates motor learning during walking in older adults with chronic stroke and identify brain structural markers that mediate this relationship. The chosen experimental design integrates biomechanical analyses, neuropsychological assessments, and brain imaging techniques to determine the impact of post-stroke cognitive impairment severity on two forms of motor learning (explicit and implicit) and examine the role of the dorsolateral prefrontal cortex in the relationship between cognition and explicit motor learning. Ultimately, this work may lead to the development of a more comprehensive, effective treatment approach to improve walking dysfunction in older adults post-stroke.

Conditions

• Stroke
• CVA (Cerebrovascular Accident)

Interventions

Type	Name	Description
BEHAVIORAL	Explicit motor learning	Participants will be provided with visual feedback of their right and left step lengths on a screen in front of a treadmill.
BEHAVIORAL	Implicit motor learning	Participants will walk on a treadmill that drives their right and left legs to move at two different speeds.

Timeline

• Start date: 2023-01-16
• Primary completion: 2026-08-14
• Completion: 2026-12-14
• First posted: 2021-04-02
• Last updated: 2025-11-04

Locations

1 site across 1 country: United States