NCT04828421

The Effect of Probiotic Supplementation on Cognitive and Emotional Functions in Healthy Elderly Subjects

The Effect of Probiotic Supplementation on Cognitive and Emotional Functions in Healthy Elderly Subjects: a Randomized, Double-blind, Cross-over and Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 36 (actual)
• Sponsor: Universidad de Almeria · Academic / Other
• Sex: All
• Age: 56 Years
• Healthy volunteers: Accepted

Summary

This study evaluates the cognitive and emotional effects of probiotics in healthy elderly patients.

Detailed description

Gut microbiota (GM) has focused as an important target for emotional and cognitive diseases, moreover in a population that show an altered GM such as elderly population as age-related changes. Several studies have shown that ageing alter GM, both in diversity and integrity. Probiotics have demonstrated that correct or prevent age-related dysbiosis, in order to reduce or prevent intestinal permeability and associated inflammation, inhibit the generation of harmful and/or toxic metabolites, as well as promote the production of beneficial bacterial components. The aim of this study is to assess the effectiveness of a multiprobiotic formulation as a therapeutic strategy to attenuate the emotional and cognitive decline associated with ageing in healthy adults over 55 years of age. The hypothesis is that administration of a multi-species probiotic for 10 weeks will slow and/or ameliorate the decline in emotional and cognitive function inherent to senescence.

Conditions

• Healthy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Lactobacillus rhamnosus and Bifidobacterium lactis	Probiotics
DIETARY_SUPPLEMENT	Placebo	Placebo

Timeline

• Start date: 2020-07-17
• Primary completion: 2022-04-30
• Completion: 2022-04-30
• First posted: 2021-04-02
• Last updated: 2022-06-01

Locations

3 sites across 1 country: Spain