NCT04825795

DPP4 Inhibitor and Coronary Atherosclerosis in Patients Receiving Insulin Therapy

Effect of DPP4 Inhibitors on Coronary Atherosclerosis in Patients With Diabetes Mellitus on Insulin Therapy

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 4,007 (actual)
• Sponsor: The Catholic University of Korea · Academic / Other
• Sex: All
• Age: 19 Years
• Healthy volunteers: Not accepted

Summary

The study aim is to evaluate whether DPP4-inhibitor could reduce coronary atherosclerosis assessed by CT scan in patients receiving insulin for diabetes mellitus. In this retrospective study, changes in obstructive coronary artery disease prevalence and coronary calcium burden between two coronary CT scans will be compared in patients with and without receiving DPP4-inhibitor.

Detailed description

This is a retrospective study using medical records in two hospitals affiliated to the Catholic University of Korea. Patients with diabetes mellitus who received insulin are retrospectively enrolled. Among those, only patients who underwent coronary CT scan for more than two times will be included. Included patients will be classified into DPP4-inhibitor group and no DPP4-inhibitor group according to the prescribed medication. The changes in obstructive coronary artery disease prevalence and coronary calcium score per one year will be compared between the two groups.

Conditions

• Diabetes Mellitus

Interventions

Type	Name	Description
DRUG	DPP4-inhibitor	Prescription of DPP4-inhibitor during the period between the two coronary CT scan
DRUG	No DPP4-inhibitor	No prescription of DPP4-inhibitor during the period between the two coronary CT scan

Timeline

• Start date: 2010-01-01
• Primary completion: 2021-02-24
• Completion: 2021-03-30
• First posted: 2021-04-01
• Last updated: 2023-02-08

Locations

1 site across 1 country: South Korea