NCT04819633

Evaluating Serum Sestrin in Leiomyoma Patients

Evaluation of Serum Sestrin Levels in Patients With Leiomyoma

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 61 (actual)
• Sponsor: Sisli Hamidiye Etfal Training and Research Hospital · Academic / Other
• Sex: Female
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Leiomyomas are the most common benign neoplasms of women's reproductive system affecting 20-30% of women within the reproductive ages. Sestrins are serum proteins which are highly expressed under circumstances of DNA damage, hypoxia and oxditive stress and play an important role in autophagia. The aim of this study is to evaluate the relationship of serum sestrin proteins with development of leiomyomas.

Detailed description

Leiomyomas are the benign neoplasms of uterus and the role of genetics, estrogen levels and obesity has already been shown in their development. Higher levels of serum sestrin proteins have already been associated with DNA damage, hypoxia and oxidative stress and sestrin plays an important role in autophagia. In order to evaluate the role of serum sestrin in the development of leiomyomas 30 patients between 18-45 years of age who were diagnosed with uterine leiomyomas with transvaginal ultrasonography will be included in the study group. Their serum sestrin levels will be determined and compared with that of 30 healthy subjects recruited during the same study period at the same clinic.

Conditions

• Uterine Leiomyoma

Interventions

Type	Name	Description
OTHER	Determination of serum sestrin levels	Serum sestrin levels will be determined using venous blood samples obtained from the subjects.

Timeline

• Start date: 2021-01-01
• Primary completion: 2021-03-01
• Completion: 2021-04-01
• First posted: 2021-03-29
• Last updated: 2021-09-21

Locations

1 site across 1 country: Turkey (Türkiye)