NCT04819204

Testosterone and Neurovascular Control in Humans

Exploring the Role of Testosterone on Neurovascular Control in Humans

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Western University, Canada · Academic / Other
• Sex: Male
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The purpose of these studies are to evaluate the role of testosterone on autonomic and vascular function in men.

Detailed description

Sex hormones play a pivotal role in neurovascular function in humans. In recent years, great strides have been made in elucidating the roles of estrogen and progesterone on autonomic and vascular control in women; however, very little is known about the impact of testosterone in men. Given that low testosterone levels are associated with an increased risk of cardiovascular disease, reduced exercise capacity and vascular dysfunction, it is evident that testosterone plays a pivotal role in autonomic and vascular function in men. Our current understanding of testosterone's effects on neurovascular control are confounded by numerous factors that independently alter autonomic and vascular function such as aging and chronic disease (e.g. cardiovascular disease, metabolic disease). The purpose of these studies are to evaluate the role of testosterone on autonomic and vascular function in young men to better isolate the effects of testosterone from the aforementioned confounding factors. The outcomes of these studies will provide novel information regarding the role of male sex hormones in autonomic and vascular control, and further our understanding of the influence of sex hormones on human physiology.

Conditions

• Healthy

Interventions

Type	Name	Description
DRUG	Cetrorelix Acetate	GnRH antagonist - subcutaneous injection. Day 1: 1-3 mg; Days 2-14: 0.25mg/daily.
DRUG	Testosterone gel	Testosterone gel - transdermal application of 5mg/day on Day 7-14 of GnRH antagonist

Timeline

• Start date: 2021-06-01
• Primary completion: 2023-12-01
• Completion: 2023-12-01
• First posted: 2021-03-26
• Last updated: 2021-03-26

Locations

1 site across 1 country: Canada