NCT04818450

Impact of Gabapentin on Slow Wave Sleep in Adult Critically Ill Patient

Impact of Gabapentin on Slow Wave Sleep in Adult Critically Ill Patient.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Mahidol University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The investigators proposed that gabapentin will increase slow-wave sleep in adult critically ill patients. Increasing slow-wave sleep will improve the patients' outcomes (shortening ICU length of stay, improving ventilator free days, increasing delirium free days) in critically ill patients, a university hospital, Thailand.

Detailed description

Up to 61% of critically ill patients have sleep deprivation in ICU. Sleep deprivation can cause delirium and lead to prolonged ICU length of stay and mechanical ventilator days. However, pharmacologic interventions to improve sleep quality and prevent sleep deprivation are poorly tested for efficacy and safety in ICU patients. There were reports of gabapentin increasing slow-wave sleep in healthy populations and insomnia patients with insignificant adverse events. Therefore, gabapentin might increase slow-wave sleep resulting in improving clinical outcomes in adult critically ill patients. The objectives of the study were to evaluate the efficacy, especially on slow-wave sleep, and safety of gabapentin in adult critically ill patients admitted to ICUs at Ramathibodi Hospital, a university hospital, Thailand.

Conditions

• Sleep Deprivation
• Critically Ill

Interventions

Type	Name	Description
DRUG	Gabapentin	Gabapentin 100-300 mg is given to the intervention group

Timeline

• Start date: 2021-04-19
• Primary completion: 2022-06-25
• Completion: 2022-07-31
• First posted: 2021-03-26
• Last updated: 2022-08-11

Locations

1 site across 1 country: Thailand