NCT04818268

Sensory Memory in Speech Motor Learning

Role of Sensory Working Memory in Speech Motor Learning Aim 2

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: Yale University · Academic / Other
• Sex: All
• Age: 21 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The proposed studies focus on memory for speech movements and sounds and its relation to learning. Continuous theta-burst transcranial magnetic stimulation (cTBS) will be used to suppress activity in a region of pre-frontal cortex associated with somatic and auditory working memory (Brodmann area 46v) to test its involvement in learning.

Detailed description

This study will assess the relationship between sensory working memory and speech motor adaptation using a between subjects design. Participants will be assigned to one of two groups. Each group will undergo both auditory and somatosensory working memory tests. This will be followed by adaptation to altered auditory feedback. Using a different group of subjects, cTBS will be used to disrupt neural activity in Brodmann area 46v in ventrolateral prefrontal cortex to test its involvement in adaptation. One set of tests will focus on the effects of cTBS on both auditory and somatosensory working memory. A second set of tests will focus on the effects of cTBS on speech motor adaptation to altered auditory feedback. Both working memory and adaptation are assessed on 0 to 100 scales.

Conditions

• Speech
• Consolidation

Interventions

Type	Name	Description
BEHAVIORAL	Adaptation	Sensorimotor adaptation in speech
OTHER	cTBS	continuous theta-burst stimulation

Timeline

• Start date: 2019-08-01
• Primary completion: 2025-07-31
• Completion: 2025-07-31
• First posted: 2021-03-26
• Last updated: 2025-12-11

Locations

1 site across 1 country: Canada